Your challenge

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with a highly unpredictable time course. Resilience – the capacity of the brain to preserve cognition in the face of evident brain damage – likely plays a major role in determining the rate of cognitive decline given a certain amount of pathology. In this project, we will bring these three elements together: 1) resilience (measured using a neuroimaging method developed in our research group or by “proxies” like education or IQ), 2) brain damage (measured using various neuroimaging techniques like PET and MRI), and 3) disease progression (measured using extensive neuropsychological assessment). The aims of this PhD project are to i) better understand the complex interactions between resilience, neurodegeneration and cognitive decline, and ii) optimize our neuroimaging method of measuring resilience for eventual application in the clinic. This should result in an improved prognosis of patients with AD. We will use large-scale (already existing) datasets for this project.

The most important duties and responsibilities as a PhD student are:

  • Conducting multi-modal imaging analyses;
  • Statistical modeling of longitudinal imaging and cognitive data;
  • Writing scientific papers resulting in a PhD thesis.

Your profile

We are seeking someone who meets the following requirements:

  • A masters degree in bioinformatics, computer science, artificial intelligence or a similar field;
  • Demonstrable experience and affinity with programming and biostatistics;
  • Experience with neuroimaging data and/or longitudinal analyses would be a strong advantage;
  • Specific interest in dementia and/or cognitive decline.

Your work environment

Alzheimer’s Center Amsterdam stands for distinctive patient care and high-quality scientific research in the field of dementia. Especially when it comes to dementia at a young age. Our mission is to make dementia negotiable, treatable and ultimately to cure dementia altoghter. With over 75 employees, we are part of the Neurology department at location VUmc. We are convinced that only by linking scientific research to patient care, the necessary progress can be made in the fight against dementia. For more information about the Alzheimer Center, click here.

We offer

Salary Scale PHD: 2357 tot 3020 euro gross when employed full-time (depending on qualifications and experience).

In addition we offer:
– Additional benefits include an 8.3% end-of-year bonus and 8% holiday pay.
– Your pension premium will be paid by us for 2/3.
– We reimburse 75% of your OV travel costs (commuting costs).

For more information about our employment conditions, please visit our website.
For Dutch citizens it is mandatory to provide a VOG (a declaration of good behaviour).

Additional information

It is a four-year promotion process. We initially offer a contract for 1 year, which can be extended by mutual agreement. The intended start date is flexible and can take place in the period between June-October 2019.


Don’t hesitate to call us!
If you’re interested about this position, you can contact Dr. Ossenkoppele, via telephone number 020-4445635.
If you need more information about the application procedure, contact Brend de Jong, corporate recruiter at 020-4445635.

You can apply till 2 June 2019 by using the apply button.

Acquisition based on this vacancy is not appreciated.