After surgical treatment for stage II and III colorectal cancer, approximately 20% of patients develops a recurrent tumor or metastases. The general assumption is that early detection of recurrence leads to increased survival, but this is not confirmed in studies on intensified follow up for all patients. However, the current follow-up protocol is uniform for all patients, while there is a high interpersonal variability in recurrence risk. Therefore, patient organizations and policy makers call for a more patient-centered, tailored follow-up. In this ZonMw funded project, we aim to develop a protocol for patient-centered follow-up for curatively treated stage II/III colorectal cancer (CRC) patients, in which intensity and setting of follow-up is adapted to the need of the patient and an individual’s risk of recurrence. The project consists of two workpackages and is a collaboration between Radboud University Medical Center (responsible for WP1) and Amsterdam UMC (responsible for WP2), University Medical Center Utrecht and The Netherlands Cancer Registry.
In the two wosppackages, we examine the following two research questions:
1) Can patient-led home-based follow-up be successfully implemented in 5 hospitals in the Netherlands?
2) Are there follow-up strategies that can further optimize patient-led home-based follow-up in terms of cost-effectiveness by tailoring the schedule to an individual’s recurrence risk?
We look for a PhD student who is enthusiastic about the challenge of answering the second research question. To tackle this question, multiple risk-based follow-up strategies will be simulated using a stage II/III CRC micro-simulation model. A model for stage II colon cancer is available, and will be extended and updated using data from the literature, the Netherlands Cancer Registry, the pathology registry PALGA and a number of clinical studies. Subsequently, the model will be used to project long-term effects of follow-up on recurrence-free survival, disease-specific and overall mortality, QALYs, cost, and cost-effectiveness.
As a PhD student your main tasks are:
- To perform epidemiological and statistical analyses underlying the construction of the decision model;
- To transform the currently existing decision model in Excel to R statistics and update and extend the model;
- To run scenario and cost-effectiveness analyses with the model;
- To publish your research findings in biomedical, epidemiological and/or public health journals and complete a PhD thesis;
- To assist in teaching activities in epidemiology courses for medical students.
We are searching for a PhD student with the following expertise and experience:
- You have a Masters degrees in Econometrics, Health Economics, Statistics or Epidemiology;
- You are interested in decision modeling and cost-effectiveness research;
- You have good verbal and written communcation skills (English);
- Experience with performing epidemiological analyses (SPSS, Stata or R) and modeling is an advantage.
Your work environment
The department of Epidemiology and Data Science at the Amsterdam Medical Centers supports and initiates biomedical, epidemiological and biostatistical research. The department also coordinates the epidemiology and statistics courses for bachelor and master students. One of the main research topics is epidemiological, mathematical and cost-effectiveness research of the prevention, diagnosis and treatment of cancer.
Working at Amsterdam UMC means working in an inspiring and professional environment where developing one`s talents and academic skills are encouraged. We offer you ample opportunity for development, deepening and broadening, additional training, and a place to grow!
Salary Scale PHD: 2495 tot 3196 euro gross when employed full-time (depending on qualifications and experience).
The monthly wage will increase yearly to the maximum salary in the fourth year of 3,196 € gross per month.
In addition, we offer:
– Additional benefits include an 8.3% end-of-year bonus and 8.0% holiday pay.
– The opportunity to follow further training and development.
– Pension is accrued at the ABP. VUmc contributes a large part of the premium (70%).
– In addition to excellent accessibility by public transport, we reimburse 75% of your OV travel costs (commuting costs).
We offer an initial contract for 12 months that will be extended (after evaluation) for another 36 months.
For more information about our employment conditions, please visit our website.
For Dutch citizens it is mandatory to provide a VOG (Verklaring Omtrent Gedrag). Foreign citizens need to provide comparable police clearing certificates.
Information and application
Don’t hesitate to call us!
If you’re interested about this position, you can contact dr. Veerle Coupé, via telephone number 020-4441049.
If you need more information about the application procedure, contact Brend de Jong, corporate recruiter at 020-4445635.
You can apply till 22 August 2021 by using the apply button.
Acquisition based on this vacancy is not appreciated.