The most common cause of dementia is Alzheimer’s disease (AD). AD starts with amyloid beta aggregation in the brain, 20 years before the onset of dementia. This long time period provides opportunities to prevent dementia. It is known that loss of brain connectivity is central to the clinical manifestation of AD. Moreover, dysconnectivity also plays a role in non-AD dementia syndromes. In this project you study the genetic factors that are associated with strong or with vulnerable brain connections as measured on MRI scans in the Amsterdam Dementia Cohort as a discovery cohort, and replicate findings in independent other large cohorts. You investigate which combined genetic and brain connectivity patterns are specific or generic across different dementia disorders, and whether genetic factors related to brain connectivity can be found that explain differences between individuals in disease progression. This research is part of a VIDI funded project and includes collaborations with the Neuroscience Campus Amsterdam, as well as with large scale European consortia.
- MSc in bioinformatics, systems biology, neuroscience, biomedical science, or related fields.
- Demonstrable experience with analysis of large complex data sets, preferably with experience in genomic fields or MRI processing;
- Experience with statistical software R, and experience with PLINK is preferred;
- Experience with Python is preferred;
- Knowledge and understanding of ontological databases such as KEGG, and GO;
- Understanding of bioinformatical tools (e.g., IPA);
- Organisational, communicative and cooperative skills, as you will collaborate with scientists from multiple scientific disciplines.
Your work environment
The Alzheimer Center Amsterdam is committed to serve patient care and advance scientific knowledge on different types of dementia. We aim for worldwide excellence in patient care and scientific research. With now over 100 colleagues we are part of the department of Neurology of the Amsterdam UMC. See our website for more information.
Working at Amsterdam UMC means working in an inspiring and professional environment where developing one`s talents and academic skills are encouraged. We offer you ample opportunity for development, deepening and broadening, additional training, and a place to grow!
Salary Scale PHD: 2495 tot 3196 euro gross when employed full-time (depending on qualifications and experience).
The monthly wage will increase yearly to the maximum salary in the fourth year of 3,196 € gross per month.
In addition, we offer:
– Additional benefits include an 8.3% end-of-year bonus and 8.0% holiday pay.
– The opportunity to follow further training and development.
– Pension is accrued at the ABP. VUmc contributes a large part of the premium (70%).
– In addition to excellent accessibility by public transport, we reimburse 75% of your OV travel costs (commuting costs).
We offer an initial contract for 12 months that will be extended (after evaluation) for another 36 months.
For more information about our employment conditions, please visit our website.
For Dutch citizens it is mandatory to provide a VOG (Verklaring Omtrent Gedrag). Foreign citizens need to provide comparable police clearing certificates.
We have an inspiring working environment with lots of music and table football.
If you have any questions about this position please contact dr. Betty Tijms, via e-mail : firstname.lastname@example.org. The selection procedure will be performed in 2 rounds: the first being an interview, the second will be an assessment. We aim for this position to start on September 1st 2021.
Information and application
Don’t hesitate to call us!
If you’re interested about this position, you can contact Merel Dorland, via telephone number 06-25716274.
If you need more information about the application procedure, contact Brend de Jong, corporate recruiter at 020-4445635.
You can apply till 8 August 2021 by using the apply button.
Acquisition based on this vacancy is not appreciated.