Due to the clinical and pathological heterogeneous nature of Alzheimer’s disease (AD), non-invasive pathology-specific imaging biomarkers for better diagnosis, prognosis and treatment strategies, are highly needed. The aim of the project is to define the pathological sensitivity of (advanced) MRI outcome measures, as biomarkers for (differential) cognitive decline in AD.
Objectives of the project are (i) to define which (combination of) neuropathological and inflammatory markers are associated with MRI outcomes used in ongoing clinical trials. (ii) to ascertain which advanced imaging biomarkers is most sensitive to specific neuropathological disease states, as defined by the distribution and burden of proteinopathy. (iii) To address AD heterogeneity with pathology-defined imaging patterns, and differentiate amnestic and non-amnestic clinical presentations. (iv) To explore if artificial intelligence can be used to gain a higher sensitivity and specificity of defining pathology-confirmed AD (subtypes).
By integrating multisource data (clinical, radiological, histopathological), the project will result in new fundamental knowledge leading to improved interpretation of imaging datasets, and contribute to better diagnosis, prognosis and monitoring paradigms in AD.
We are looking for smart, skilled and creative neuroscientists, with a relentless eagerness to learn, a broad interest in neuroscience and a healthy disregard of potential ‘bumps in the road’ within the scope of these high-risk-high-gain studies. Its important that you have a flexibel attitude and you are available to work flexible hours when the circumstances in the project require. You will be part of a young, multidisciplinary team, with ample experience, and an excellent position within the expert field.
As a PhD student your main duties and responsibilities are:
- Setting up and conducting the research;
- Coordinating and assisting at brain autopsies;
- Performing MRI data analysis;
- Performing histological stainings in combination with microscopic techniques;
- Writing scientific articles based on the results of your research;
- Writing a dissertation.
In addition we are looking for a PhD student who:
- have a master’s degree in neurosciences, biomedical sciences or equivalent training;
- have experience/strong affinity with MRI analysis and/or for performing histological stainings and image analysis.
Your work environment
The Department of Anatomy & Neurosciences at Amsterdam UMC, location Vumc, offers a multidisciplinary environment for research and (post)academic education. With internationally acclaimed research programs, the pathophysiology of neurodegenerative diseases and (neuro)psychiatric disorders is broadly investigated, in a translational fashion.
Within the department, the Clinical Neuroanatomy and Biobanking (CNAB) team aims to translate basic preclinical research to the clinical setting and vice versa. Several CNAB fellows work on molecular and cellular mechanisms of neuropathology, while others translate these findings via high-tech post mortem and in vivo imaging techniques to the clinical setting where neurological patients are investigated, monitored, and treated. For more information we invite you to take a look on the anatomy & neurosciences website or the Normal Aging Brain Collection Amsterdam website.
Salary Scale OIO: 2495 tot 3196 euro gross when employed full-time (depending on qualifications and experience).
The monthly wage will increase yearly to the maximum salary in the fourth year of 3,196 € gross per month.
In addition, we offer:
– Additional benefits include an 8.3% end-of-year bonus and 8% holiday pay.
– Your pension premium will be paid by us for 2/3.
– We reimburse 75% of your OV travel costs (commuting costs).
It is a 4-year promotion project. We initially offer a contract for 1 year, which can be extended by mutual agreement.
For more information about our employment conditions, please visit our website.
For Dutch citizens it is mandatory to provide a VOG (a declaration of good behaviour).
The preferred starting date for this position is October 2021, but is negotiable.
The first interviews are scheduled for the last week of August 2021
Information and application
Don’t hesitate to call us!
If you’re interested about this position, you can contact Laura Jonkman, via telephone number 0653932447.
If you need more information about the application procedure, contact Brend de Jong, corporate recruiter at 020-4445635.
You can apply till 16 August 2021 by using the apply button.
Acquisition based on this vacancy is not appreciated.