Alzheimer’s is the most common cause of dementia among older adults. The pathology of the disease is characterized by the deposition of amyloid beta and tau tangles in the brain leading to neurodegeneration. In the last decade several antibodies that target amyloid beta and tau aggregates have been developed to treat the disease but despite their specificity and selectivity to the target they failed in showing clinical improvement in patients. The main reason for the lack of efficacy of these antibodies is believed to be their poor ability to cross the blood brain barrier and enter the brain. The project is a part of a collaboration with the pharmaceutical industry for the evaluation of novel antibody constructs for PET imaging and treatment of Alzheimer’s disease. The finance for the postdoc position is for two years.
Your task will be to evaluate in vivo and ex vivo novel antibody constructs targeting amyloid beta. You will radiolabel these antibody constructs with zirconium-89 and you will evaluate their biodistribution in animal models of Alzheimer’s disease. You will also perform positron emission tomography (PET) imaging in order to evaluate the ability of these construct to image the deposition of amyloid beta in the brain. In addition, you will perform ex vivo validations like autoradiography and immunohistochemistry.
You are also expected to contribute in the scientific development of the group, supervise PhD students and technicians, and publish results in high-ranked journals.
We are looking for a dedicated and skilled individual with excellent analytical skills, good command of written and spoken English and should be able to work in a team as well as independently. You also have the following qualifications:
- A PhD in life sciences, neurosciences, or PET imaging;
- Interest in molecular imaging and experience with neurological diseases and PET neuroimaging in rodents;
- Experience in preclinical evaluation of radiopharmaceuticals, both in vitro, in vivo, and ex vivo including PET imaging, biodistribution, immunohistochemistry;
- Preferably experience with radiolabeling of antibodies with Zirconium-89;
- A strong scientific record, including publications in high-ranked journals;
- Experience in supervising technician, bachelor and master students;
- Excellent communication skills;
- Passed the course in Laboratory Animal Science EU Function ABD (formerly FELASA Category C);
- Preferably passed the 5B course certificate.
Your work environment
The department of Radiology & Nuclear Medicine is, amongst others, specialized in conducting research using nuclear imaging techniques, more specifically Positron Emission Tomography (PET). Our aim is to use PET for diagnosis of disease, treatment monitoring and patient selection. Tracer Center Amsterdam develops the new PET tracers needed in the clinic for neurological diseases as well as oncology, rheumatology and cardiology. The research of TCA focusses on radiochemistry methodology development, selection of biological targets and development of new PET tracers for these targets, preclinical in vivo evaluation of new PET tracers as well as good manufacturing practice (GMP)-compliant synthesis of PET tracers.
In 2019 we will move into the Amsterdam UMC Imaging Center equipped with a brand new lab for TCA according to current state of the art. At the Imaging Center all imaging modalities will come together and the synergy with the clinic will be further enhanced.
TCA collaborates with many national and international research institutes and pharmaceutical companies and is partner in several ITN-EU funded programs (PET3D, RadioMI).
VUmc wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Salary Scale 10: 2750 tot 4361 euro gross when employed full-time (depending on qualifications and experience).
In addition we offer:
– Additional benefits include an 8.3% end-of-year bonus and 8% holiday pay.
– Your pension premium will be paid by us for 2/3.
– We reimburse 75% of your OV travel costs.
For more information about our employment conditions, please visit our website.
Extensive screening will form part of the selection procedure. As part of this screening, we will require a Certificate of Good Conduct (VOG).
If you want to apply please include a motivation letter and curriculum vitae, as well as a list of peer reviewed publications, possible letters of recommendation and diplomas who you can upload as one additional document.
The position is to start as soon as possible.
Don’t hesitate to call us!
If you’re interested about this position, you can contact dr. W. Beaino at +3120444 5544, Prof. dr. A.D. Windhorst at +31204449707 or dr. D. Vugts, via telephone number +3120 444 5699.
If you need more information about the application procedure, contact Brend de Jong, corporate recruiter at +3120 444 5635.
You can apply till 31 March 2019 by using the apply button.
Acquisition based on this vacancy is not appreciated.