The research group Clinical Neuroanatomy and Biobanking of the dept. of Anatomy & Neurosciences (ANW) focuses on understanding the neuropathological and neuroanatomical substrates underlying cognitive decline and dementia in Parkinson’s disease and identification of novel diagnostic biomarkers and disease-modifying therapies for this devastating disorder. In close collaboration with (international) academic and industry partners, we are studying the structure, function and aggregation of the protein alpha-synuclein in biospecimen of patients with neurodegenerative disorders to provide insight in the disease mechanisms underlying alpha-synuclein toxicity. Alpha-synuclein accumulates and aggregates in neurons and glial cells in the central, enteric and pheripheral nervous system. In the current project, we will study the structure of alpha-synuclein in postmortem brain tissue of patients with Parkinson’s disease, Alzheimer’s disease, Dementia with Lewy bodies and related neurodegenerative disorders using novel antibodies, multiplex biochemistry and advanced correlative microscopy techniques. This knowledge will contribute to understanding alpha-synuclein neurotoxicity, which is essential for the development of novel therapeutic strategies to halt or stop disease progression in Parkinson’s and related neurodegenerative disorders.
As an assistant-researcher, your main responsibilities are:
- Assist in the pathological characterization quantification of neuropathological lesions in brain tissue of donor with PD or other neurodegenerative disorders;
- Dissect anatomical regions and neuropathological lesions from postmortem brain tissue of individuals with PD or related neurodegenerative disorders using laser capture microdissection and processing tissue for multiplex biochemical and molecular analysis;
- Study the subcellular localization and morphology of alpha-synuclein forms in the selected brain regions using a LEICA TCS SP8 STED 3x super-resolution microscope;
- Interact and communicate with academic and industry partners about the results in the project.
We are searching for a highly motivated and enthusiastic assistant-researcher with the following expertise:
- Experience research technician with histological or biochemical expertise or MSc degree in biomedical sciences, biochemistry or neuroscience and lab experience;
- You preferably have experience with neuroanatomy of the human brain, immunofluorescence, confocal laserscanning microscopy (CSLM) and biochemical assays (western blotting, ELISA, AlphaLisa).
Our ideal candidate can strengthen our team both on a scientific as organizational level;
- Excellent Dutch and English communications skills, both written and verbal.
Your work environment
With internationally acclaimed research programs, the pathophysiology of neurodegenerative diseases and psychiatric disorders is broadly investigated, in a translational fashion at the dept. of Anatomy & Neurosciences (ANW) of Amsterdam UMC, location VUmc. Innovative fundamental neuroscientific research is translated to the clinical setting, where the patient can directly benefit from the latest insights of neuroscience.
Working at Amsterdam UMC means working in an inspiring and professional environment in which developing one`s talents and skills is encouraged. The ANW department, as it is positioned at the cutting edge of society and science, offers a multidisciplinary environment for research and (post)academic education.
Salary Scale 7: 2422 tot 3280 euro gross when employed full-time (depending on qualifications and experience).
In addition we offer:
– Additional benefits include an 8.3% end-of-year bonus and 8% holiday pay.
– The opportunity to follow further training and development.
– Pension is accrued at the ABP. VUmc contributes a large part of the premium (70%).
– In addition to excellent accessibility by public transport, we reimburse 75% of your OV travel costs (commuting costs).
We offer an initial contract for 12 months that can be extended (after evaluation).
For more information about our employment conditions, please visit our website.
For Dutch citizens it is mandatory to provide a VOG (Verklaring Omtrent Gedrag).
The starting date of this position is as soon as possible, but is negotiable.
This project is a collaboration with various other departments within VUmc, with (academic) partners at ETH Zurich and Goettingen and industry partners.
Information and application
Don’t hesitate to call us!
If you’re interested about this position, you can contact Dr. Wilma van de Berg, associate professor Anatomy and Neurosciences, via telephone number 020 444 8704.
If you need more information about the application procedure, contact Brend de Jong, corporate recruiter at 020 444 8704.
You can apply till 13 May 2021 by using the apply button.
Acquisition based on this vacancy is not appreciated.